CARP LAB

Cardiac Arrhythmia Research Program

Google Scholar Search

Articles

2026

Recovering intrinsic conduction velocity and action potential duration from electroanatomic mapping data using curvature.
Roney C, Plank G, Honarbakhsh S, Vidal Horrach C, Pezzuto S, Vigmond E.
Med Image Anal. 2026 Jan;107(Pt A):103809.
Integrating Imaging and Invasive Pressure Data into a Multiscale Whole-Heart Model.
Strocchi M, Augustin CM, Gsell MAF, Rinaldi CA, Vigmond EJ, Plank G, Oates CJ, Wilkinson RD, Niederer SA.
J Biomech Eng. 2026 May 1;148(5):051001.
In silico trials for sex-specific patient inclusion criteria in cardiac resynchronization therapy.
Qian, Shuang and Ugurlu, Devran and Fairweather, Elliot and Jones, Richard E and Zaidi, Hassan and Prasad, Sanjay and Halliday, Brian P and Hammersley, Daniel and Plank, Gernot and Vigmond, Edward and others.
npj Digital Medicine. 2026.
Analysis of sex and BMI influence on power delivery in high-power RF ablation for atrial fibrillation using virtual patient simulations.
Anees, Minha and Moreno Weidmann, Zoraida and Vilad{\'e}s Medel, David and Neic, Aurel and Vigmond, Edward J and Guerra, Jose M and Gerardo-Giorda, Luca and Petras, Argyrios.
Scientific Reports. 2026.
JAX-EP: A Fully Differentiable Monodomain Solver for Cardiac Electrophysiology},.
Jaffery, Ovais Ahmed and Ehnesh, Mahmoud and Valli, H and Slabaugh, Gregory and Vigmond, Edward J and Haldar, Shouvik and Roney, Caroline H.
Research Square. 2026.

2025

Atrial fibrillation nomenclature, definitions, and mechanisms: Position paper from the international Working Group of the Signal Summit.
de Groot NMS, Kleber A, Narayan SM, Ciaccio EJ, Doessel O, Bernus O, Berenfeld O, Callans D, Fedorov V, Hummel J, Haissaguerre M, Natale A, Trayanova N, Spector P, Vigmond E, Anter E.
Heart Rhythm. 2025 Jun;22(6):1480-1491.
Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization.
Qian S, Ugurlu D, Fairweather E, Toso LD, Deng Y, Strocchi M, Cicci L, Jones RE, Zaidi H, Prasad S, Halliday BP, Hammersley D, Liu X, Plank G, Vigmond E, Razavi R, Young A, Lamata P, Bishop M, Niederer S.
Nat Cardiovasc Res. 2025 May;4(5):624-636.
Hexagonal Multielectrode Design for Recording Local Electrograms With Superior Characteristics.
Hoogendijk MG, Coronel R, Arora R, Kuiper M, de Groot N, de Boer RA, Vigmond EJ, Boukens BJ.
JACC Clin Electrophysiol. 2025 Jul;11(7):1606-1612.
An in silico guide for ventriculo-ventricular delay programming for left bundle branch-optimized cardiac resynchronization therapy.
Strocchi M, Samways JW, Naraen A, Ali N, Shun-Shin MJ, Gillette K, Rinaldi CA, Arnold AD, Plank G, Vigmond EJ, Whinnett ZI, Niederer SA.
Europace. 2025 May 7;27(5):euaf089.
The Accuracy of Cardiac Surface Conduction Velocity Measurements.
Vigmond EJ, Massé S, Roney CH, Bayer JD, Nanthakumar K.
JACC Clin Electrophysiol. 2025 Apr;11(4):694-705.
Scientific criticism. A plea for continuous and open peer review.
Vigmond E, Coronel R.
Front Physiol. 2025 Sep 4;16:1661509.
Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions.
Jabbour RJ, Behradfar E, Debney M, Nygren A, Hartley A, Efimov I, Hocini M, Peters NS, Ng FS, Vigmond EJ.
Front Physiol. 2025 May 6;16:1540400
Microvolt Activation Alternans Identifies Conduction Velocity Heterogeneity and the Entrance Site of Ischemic Ventricular Tachycardia.
Denham NC, Suszko AM, Nemaire M, Bhaskaran A, Massé S, Nanthakumar K, Haïssaguerre M, Downar E, Vigmond E, Chauhan VS.
JACC Clin Electrophysiol. 2025 Jun;11(6):1114-1128.
Left atrial deceleration outperforms regional conduction velocity in predicting arrhythmia recurrence following atrial fibrillation ablation.
Massin SZ, Denham N, Kakarla J, Suszko A, Ha ACT, Singh SM, Hans AK, Vigmond E, Chauhan VS.
Heart Rhythm O2. 2025 Apr 2;6(7):928-939.
In Silico Trials for Sex-Specific patient Inclusion Criteria in Cardiac Resynchronization Therapy: Advancing Precision in Heart Failure Treatment.
Qian S, Ugurlu D, Fairweather E, Jones RE, Zaidi H, Prasad S, Halliday BP, Hammersley DJ, Plank G, Vigmond E, Rinaldi CA, Young A, Lamata P, Bishop M, Niederer S.
ArXiv [Preprint]. 2025 May 21:arXiv:2505.15708v1.
An efficient end-to-end computational framework for the generation of ECG calibrated volumetric models of human atrial electrophysiology.
Zappon E, Azzolin L, Gsell MAF, Thaler F, Prassl AJ, Arnold R, Gillette K, Kariman M, Manninger-Wünscher M, Scherr D, Neic A, Urschler M, Augustin CM, Vigmond EJ, Plank G.
ArXiv [Preprint]. 2025 Feb 5:arXiv:2502.03322v1. Update in: Med Image Anal. 2026 Jan;107(Pt B):103822.
To reconnect or not reconnect distal Purkinje fibers, that is the question when modeling the Purkinje fiber network.
Bayer JD, Gillette K, Coronel R, Plank G, Vigmond EJ.
Front Physiol. 2025 Sep 1;16:1657611.
A computational study on the influence of antegrade accessory pathway location on the 12-lead electrocardiogram in Wolff-Parkinson-White syndrome.
Gillette K, Winkler B, Kurath-Koller S, Scherr D, Vigmond EJ, Bär M, Plank G.
Europace. 2025 Feb 5;27(2):euae223.
Rhythm control benefits left ventricular function compared with rate control in patients with atrial fibrillation: A computational study.
Barrows RK, Augustin CM, Gsell MAF, Roney CH, Solís Lemus JA, Xu H, Young AA, Rajani R, Whitaker J, Vigmond EJ, Bishop MJ, Plank G, Strocchi M, Niederer SA.
Heart Rhythm O2.2025 May 9;6(7):1011-1019.
Increased extracellular volume after aortic valve replacement: A footprint of reverse ventricular remodeling that does not affect conduction velocity.
Sobota V, Augustin CM, Plank G, Vigmond EJ, Nordmeyer S, Bayer JD.
J Cardiovasc Magn Reson. 2025 Aug 6;27(2):101936
Comparing the effects of left bundle branch pacing and leadless right ventricular pacing on intraventricular and interventricular dyssynchrony using in silico modelling.
Liew A, Strocchi M, Rodero C, Gillette KK, Wijesuriya N, Howell S, de Vere F, Vigmond EJ, Plank G, Niederer S, Rinaldi CA.
Front Physiol. 2025 Oct 8;16:1644520.
Remodeling of sarcoplasmic reticulum Ca2+ uptake in cardiac Purkinje cells after ischemic myocardial infarction in various large mammalian species and humans.
Stuyvers BD, Guo Y, Dun W, Boyden PA, Amin R, Wiede L, Doré J, Hopkinson Z, Ter Keurs HEDJ, Haissaguerre M, Hocini M, Brette F, Bernus O, Chaigne S, Quesson B, Vigmond E.
Am J Physiol Cell Physiol. 2025 Nov 25.
The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability
Sobota, Vladimír and Stoks, Job and Patel, Kiran Haresh Kumar and Shetty, Roshni and Ni, Haibo and Grandi, Eleonora and Ng, Fu Siong and Volders, Paul G. A. and Cluitmans, Matthijs J. M. and Bayer, Jason D.
The Journal of Physiology (2025)

2024

Developing Cardiac Digital Twins at Scale: Insights from Personalised Myocardial Conduction Velocity
Qian, S., Ugurlu, D., Fairweather, E., Strocchi, M., Toso, L. D., Deng, Y., Plank, G., Vigmond, E., Razavi, R., Young, A., Lamata, P., Bishop, M., Niederer, S.
medRxiv (2024) 10
Distinct Substrates of Idiopathic Ventricular Fibrillation Revealed by Arrhythmia Characteristics on Implantable Cardioverter-Defibrillator
Ha\xefssaguerre, Michel et. al.
JACC: Clinical Electrophysiology (2024) 10
A computational study on the influence of antegrade accessory pathway location on the 12-lead electrocardiogram in Wolff\u2013Parkinson\u2013White syndrome
Gillette, K., Winkler, B., Kurath-Koller, S., Scherr, D., Vigmond, E. J., B\xe4r, M., Plank, G.
EP Europace (2024) 27
Electrophysiological Characteristics Associated With Spontaneous Termination of Ventricular Fibrillation
C. Monaco, G. Cheniti, K. Benali, J. Duchateau, K. Vlachos, F. Sacher, S. Ploux, E. Vigmond, O. Bernus and M. Ha\xefssaguerre
JACC: Clinical Electrophysiology (2024) 10
Omnipolar conduction velocity mapping for ventricular substrate characterization: Impact of CV estimation method and EGM type on in vivo conduction velocity measurements
Tonko, Johanna B. et al.
Heart Rhythm (2024), 21(12), 2499 - 2508
Gordon Research Conference on Cardiac Arrhythmia Mechanisms 2023: early career investigators\u2019 views on emerging concepts and technologies
Ramadan, A., Chleilat, E., Martinez-Navarro, H., Brennan-McLean, J., Copier, J., Caldwell, J., Greiner, J., Mart\xednez D\xedaz, P., Sobota, V.
The Journal of Physiology (2024) 602
Combined inhibition of atrial-specific potassium currents as a possible anti-arrhythmic drug therapy: A match made in silico
Sobota, Vladim\xedr
The Journal of Physiology (2024)
A His bundle pacing protocol for suppressing ventricular arrhythmia maintenance and improving defibrillation efficacy.
Bayer, J. D., Sobota, V., Bear, L. R., Ha\xefssaguerre, M., & Vigmond, E. J. (2024).
Computer Methods and Programs in Biomedicine, 253, 108239.
ForCEPSS-A framework for cardiac electrophysiology simulations standardization.
Gsell, M. A. F., Neic, A., Bishop, M. J., Gillette, K., Prassl, A. J., Augustin, C. M., \u2026 Plank, G.
Computer Methods and Programs in Biomedicine, 251(108189), 108189.
Activation signatures for identifying critical isthmi of ventricular tachyarrhythmias.
Nanthakumar, K., & Vigmond, E. J.
Journal of Cardiovascular Electrophysiology, 35(5), 1005\u20131006.
Interpretation of field and LEAP potentials recorded from cardiomyocyte monolayers.
Ernault, A. C., Al-Shama, R. F. M., Li, J., Devalla, H. D., de Groot, J. R., Coronel, R., \u2026 Boukens, B. J.
American Journal of Physiology. Heart and Circulatory Physiology, 326(3), H800\u2013H811.
The Accuracy of Cardiac Surface Conduction Velocity Measurements
Vigmond, E. J., Roney, C., Bayer, J., & Nanthakumar, K. (2024).
medRxiv.

2023

Constructing bilayer and volumetric atrial models at scale
Roney, C. H., Solis Lemus, J. A., Lopez Barrera, C., Zolotarev, A., Ulgen, O., Kerfoot, E., \u2026 Niederer, S. (2023).
Interface Focus, 13(6), 20230038.
Developing cardiac digital twins at scale: Insights from personalised myocardial conduction velocity.
Qian, S., Ugurlu D., Fairweather, E., Strocchi, M., Toso, L. D., Deng, Y., \u2026 Niederer, S. (2023).
medRxiv: The Preprint Server for Health Sciences.
Cardiac structure discontinuities revealed by ex-vivo microstructural characterization. A focus on the basal inferoseptal left ventricle region.
Cabanis, P., Magat, J., Rodriguez-Padilla, J., Ramlugun, G., Yon, M., Bihan-Poudec, Y., \u2026 Ozenne, V. (2023).
Journal of Cardiovascular Magnetic Resonance, 25(1), 78.
Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators.
Strocchi, M., Longobardi, S., Augustin, C. M., Gsell, M. A. F., Petras, A., Rinaldi, C. A., \u2026 Niederer, S. A. (2023).
PLoS Computational Biology, 19(6), e1011257.
Attenuation of stretch-induced arrhythmias following chemical ablation of Purkinje fibres, in isolated rabbit hearts.
Hurley, M., Walton, R., Vigmond, E. J., Ha\xefssaguerre, M., Bernus, O., & White, E. (2023).
Frontiers in Physiology, 14, 1154157.
Atrial Periodic Source Spectrum from preoperative body surface potentials predicts long-term recurrence of atrial fibrillation.
Feng, Y., Dubois, R., Hocini, M., & Vigmond, E. J. (2023).
IEEE Transactions on Bio-Medical Engineering, 70(7), 2131\u20132138.
Mechanoelectric effects in healthy cardiac function and under Left Bundle Branch Block pathology.
Petras, A., Gsell, M. A. F., Augustin, C. M., Rodriguez-Padilla, J., Jung, A., Strocchi, M., \u2026 Vigmond, E. J. (2023).
Computers in Biology and Medicine, 156(106696), 106696.
Two-to-one Purkinje-to-myocardium activation during ventricular fibrillation associated with hypertrophic cardiomyopathy.
Waldmann, V., Iserin, F., Vigmond, E., Marijon, E., Bonnet, D., Lavergne, T., & Haissaguerre, M. (2023).
HeartRhythm Case Reports, 9(2), 113\u2013117.
A comprehensive framework for evaluation of high pacing frequency and arrhythmic optical mapping signals.
Ramlugun, G. S., Kulkarni, K., Pallares-Lupon, N., Boukens, B. J., Efimov, I. R., Vigmond, E. J., \u2026 Walton, R. D. (2023).
Frontiers in Physiology, 14, 734356.
Effect of scar and His-Purkinje and myocardium conduction on response to conduction system pacing.
Strocchi, M., Gillette, K., Neic, A., Elliott, M. K., Wijesuriya, N., Mehta, V., \u2026 Niederer, S. A. (2023).
Journal of Cardiovascular Electrophysiology, 34(4), 984\u2013993.
Orientation of conduction velocity vectors on cardiac mapping surfaces.
Padilla, J. R., Anderson, R. D., Joens, C., Masse, S., Bhaskaran, A., Niri, A., \u2026 Nanthakumar, K.
European Pacing, Arrhythmias, and Cardiac Electrophysiology, 25(3), 1172\u20131182.
The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest.
Cluitmans, M. J. M., Bayer, J., Bear, L. R., Ter Bekke, R. M. A., Heijman, J., Coronel, R., & Volders, P. G. A. (2023).
Frontiers in Cardiovascular Medicine, 10, 1121517.

2022

Leadless biventricular left bundle and endocardial lateral wall pacing versus left bundle only pacing in left bundle branch block patients.
Strocchi, M., Wijesuriya, N., Elliott, M. K., Gillette, K., Neic, A., Mehta, V., \u2026 Niederer, S. A. (2022).
Frontiers in Physiology, 13, 1049214.
A personalized real-time virtual model of whole heart electrophysiology.
Gillette, Hamilton, Gsell, M. A. F., Strocchi, M., Grandits, T., Neic, A., Manninger, M., \u2026 Plank, G. (2022).
Frontiers in Physiology, 13, 907190.
Comparison between conduction system pacing and cardiac resynchronization therapy in right bundle branch block patients.
Strocchi, M., Gillette, K., Neic, A., Elliott, M. K., Wijesuriya, N., Mehta, V., \u2026 Niederer, S. A. (2022).
Frontiers in Physiology, 13, 1011566.
Dependence of epicardial T-wave on local activation voltage in Brugada syndrome.
Haissaguerre, M., Cheniti, G., Nademanee, K., Sacher, F., Duchateau, J., Coronel, R., \u2026 Bernus, O. (2022).
Heart Rhythm, 19(10), 1686\u20131688.
Correction: Linking statistical shape models and simulated function in the healthy adult human heart.
Rodero, C., Strocchi, M., Marciniak, M., Longobardi, S., Whitaker, J., O\u2019Neill, M. D., \u2026 Niederer, S. A. (2022).
PLoS Computational Biology, 18(5), e1010196.
On the electrophysiology and mapping of intramural arrhythmic focus.
Anderson, R. D., Rodriguez Padilla, J., Joens, C., Masse, S., Bhaskaran, A., Magtibay, K., \u2026 Nanthakumar, K. (2022).
Circulation. Arrhythmia and Electrophysiology, 15(5), e010384.
Detection of focal source and arrhythmogenic substrate from body surface potentials to guide atrial fibrillation ablation.
Feng, Y., Roney, C. H., Bayer, J. D., Niederer, S. A., Hocini, M., & Vigmond, E. J. (2022).
PLoS Computational Biology, 18(3), e1009893.
Impact of intraventricular septal fiber orientation on cardiac electromechanical function.
Rodr\xedguez-Padilla, J., Petras, A., Magat, J., Bayer, J., Bihan-Poudec, Y., El Hamrani, D., \u2026 Vigmond, E. (2022).
American Journal of Physiology. Heart and Circulatory Physiology, 322(6), H936\u2013H952.
Predicting atrial fibrillation recurrence by combining population data and virtual cohorts of patient-specific left atrial models.
Roney, C. H., Sim, I., Yu, J., Beach, M., Mehta, A., Alonso Solis-Lemus, J., \u2026 Niederer, S. A. (2022).
Circulation. Arrhythmia and Electrophysiology, 15(2), e010253.
The Purkinje network plays a major role in low-energy ventricular defibrillation.
Bayer, J. D., Sobota, V., Moreno, A., Ja\xefs, P., & Vigmond, E. J. (2022).
Computers in Biology and Medicine, 141(105133), 105133.
Determining anatomical and electrophysiological detail requirements for computational ventricular models of porcine myocardial infarction.
Mendonca Costa, C., Gemmell, P., Elliott, M. K., Whitaker, J., Campos, F. O., Strocchi, M., \u2026 Bishop, M. J. (2022).
Computers in Biology and Medicine, 141(105061), 105061.
Impact of anatomical reverse remodelling in the design of optimal quadripolar pacing leads: A computational study.
Rodero, C., Strocchi, M., Lee, A. W. C., Rinaldi, C. A., Vigmond, E. J., Plank, G., \u2026 Niederer, S. A. (2022).
Computers in Biology and Medicine, 140(105073), 105073.
Multisite conduction block in the epicardial substrate of Brugada syndrome.
Ha\xefssaguerre, M., Nademanee, K., Sacher, F., Cheniti, G., Hocini, M., Surget, E., \u2026 Bernus, O. (2022).
Heart Rhythm, 19(3), 417\u2013426.
Low-energy, single-pulse surface stimulation defibrillates large mammalian ventricles.
Moreno, A., Walton, R. D., Bernus, O., Vigmond, E. J., & Bayer, J. D. (2022).
Heart Rhythm, 19(2), 308\u2013317.

2021

A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation.
Augustin, C. M., Gsell, M. A. F., Karabelas, E., Willemen, E., Prinzen, F. W., Lumens, J., \u2026 Plank, G. (2021).
Computer Methods in Applied Mechanics and Engineering, 386(114092), 114092.
Automated framework for the inclusion of a His-Purkinje system in cardiac digital twins of ventricular electrophysiology.
Gillette, K., Gsell, M. A. F., Bouyssier, J., Prassl, A. J., Neic, A., Vigmond, E. J., & Plank, G. (2021).
Annals of Biomedical Engineering, 49(12), 3143\u20133153.
Noninvasive detection of spatiotemporal activation-repolarization interactions that prime idiopathic ventricular fibrillation.
Cluitmans, M. J. M., Bear, L. R., Nguy\xean, U. C., van Rees, B., Stoks, J., Ter Bekke, R. M. A., \u2026 Volders, P. G. A. (2021).
Science Translational Medicine, 13(620), eabi9317.
A computational model of pig ventricular cardiomyocyte electrophysiology and calcium handling: Translation from pig to human electrophysiology.
Gaur, N., Qi, X.-Y., Benoist, D., Bernus, O., Coronel, R., Nattel, S., & Vigmond, E. J. (2021).
PLoS Computational Biology, 17(6), e1009137.
The openCARP simulation environment for cardiac electrophysiology.
Plank, G., Loewe, A., Neic, A., Augustin, C., Huang, Y.-L., Gsell, M. A. F., \u2026 Vigmond, E. J. (2021).
Computer Methods and Programs in Biomedicine, 208(106223), 106223.
A novel method to correct repolarization time estimation from unipolar electrograms distorted by standard filtering.
Langfield, P., Feng, Y., Bear, L. R., Duchateau, J., Sebastian, R., Abell, E., \u2026 Vigmond, E.
Medical Image Analysis, 72(102075), 102075.
A Framework for the generation of digital twins of cardiac electrophysiology from clinical 12-leads ECGs.
Gillette, K., Gsell, M. A. F., Prassl, A. J., Karabelas, E., Reiter, U., Reiter, G., \u2026 Plank, G. (2021).
Medical Image Analysis, 71(102080), 102080.
Estimation of personalized minimal Purkinje systems from human electro-anatomical maps.
Barber, F., Langfield, P., Lozano, M., Garcia-Fernandez, I., Duchateau, J., Hocini, M., \u2026 Sebastian, R. (2021).
IEEE Transactions on Medical Imaging, 40(8), 2182\u20132194.
How electrode position affects selective His bundle capture: A modelling study.
Vigmond, E. J., Neic, A., Blauer, J., Swenson, D., & Plank, G. (2021).
IEEE Transactions on Bio-Medical Engineering, 68(11), 3410\u20133416.
On the nature of delays allowing anatomical re-entry involving the Purkinje network: a simulation study.
Vigmond, E. J., Bouyssier, J., Bayer, J., Ha\xefssaguerre, M., & Ashikaga, H. (2021).
European Pacing, Arrhythmias, and Cardiac Electrophysiology, 23(23 Suppl 1), i71\u2013i79.
Transient receptor potential vanilloid 4 channel participates in mouse ventricular electrical activity.
Chaigne, S., Cardouat, G., Louradour, J., Vaillant, F., Charron, S., Sacher, F., \u2026 Hof, T. (2021).
American Journal of Physiology. Heart and Circulatory Physiology, 320(3), H1156\u2013H1169.
Constructing a human atrial fibre atlas.
Roney, C. H., Bendikas, R., Pashakhanloo, F., Corrado, C., Vigmond, E. J., McVeigh, E. R., \u2026 Niederer, S. A. (2021).
Annals of Biomedical Engineering, 49(1), 233\u2013250.

2020

In silico comparison of left atrial ablation techniques that target the anatomical, structural, and electrical substrates of atrial fibrillation.
Roney, C. H., Beach, M. L., Mehta, A. M., Sim, I., Corrado, C., Bendikas, R., \u2026 Niederer, S. A. (2020).
Frontiers in Physiology, 11, 1145.
An inverse Eikonal method for identifying ventricular activation sequences from epicardial activation maps.
Grandits, T., Gillette, K., Neic, A., Bayer, J., Vigmond, E., Pock, T., & Plank, G. (2020).
Journal of Computational Physics, 419(109700), 109700.
A computational investigation into rate-dependant vectorcardiogram changes due to specific fibrosis patterns in non-isch\xe6mic dilated cardiomyopathy.
Gemmell, P. M., Gillette, K., Balaban, G., Rajani, R., Vigmond, E. J., Plank, G., & Bishop, M. J. (2020).
Computers in Biology and Medicine, 123(103895), 103895.
His-bundle and left bundle pacing with optimized atrioventricular delay achieve superior electrical synchrony over endocardial and epicardial pacing in left bundle branch block patients.
Strocchi, M., Lee, A. W. C., Neic, A., Bouyssier, J., Gillette, K., Plank, G., \u2026 Niederer, S. A. (2020).
Heart Rhythm, 17(11), 1922\u20131929.
Heart Rhythm best paper 2021.
A publicly available virtual cohort of four-chamber heart meshes for cardiac electro-mechanics simulations.
Strocchi, M., Augustin, C. M., Gsell, M. A. F., Karabelas, E., Neic, A., Gillette, K., \u2026 Niederer, S. A. (2020).
PloS One, 15(6), e0235145.
Direct comparison of a novel antitachycardia pacing algorithm against present methods using virtual patient modeling.
Swenson, D. J., Taepke, R. T., Blauer, J. J. E., Kwan, E., Ghafoori, E., Plank, G., \u2026 Ranjan, R. (2020).
Heart Rhythm, 17(9), 1602\u20131608.
Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia.
Gaur, N., Ortega, F., Verkerk, A. O., Mengarelli, I., Krogh-Madsen, T., Christini, D. J., \u2026 Vigmond, E. J. (2020).
Journal of Molecular and Cellular Cardiology, 145, 122\u2013132.
The \u2018Digital Twin\u2019 to enable the vision of precision cardiology.
Corral-Acero, J., Margara, F., Marciniak, M., Rodero, C., Loncaric, F., Feng, Y., \u2026 Lamata, P. (2020).
European Heart Journal, 41(48), 4556\u20134556.
Simulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium.
Strocchi, M., Gsell, M. A. F., Augustin, C. M., Razeghi, O., Roney, C. H., Prassl, A. J., \u2026 Niederer, S. A. (2020).
Journal of Biomechanics, 101(109645), 109645.

2019

Wide-area low-energy surface stimulation of large mammalian ventricular tissue.
Moreno, A., Walton, R. D., Constantin, M., Bernus, O., Vigmond, E. J., & Bayer, J. D. (2019).
Scientific Reports, 9(1), 15863.
Acetylcholine delays atrial activation to facilitate atrial fibrillation.
Bayer, J. D., Boukens, B. J., Krul, S. P. J., Roney, C. H., Driessen, A. H. G., Berger, W. R., \u2026 de Groot, J. R. (2019).
Frontiers in Physiology, 10, 1105.
Editorial: Recent advances in understanding the basic mechanisms of atrial fibrillation using novel computational approaches.
Zhao, J., Aslanidi, O., Kuklik, P., Lee, G., Tse, G., Niederer, S., & Vigmond, E. J. (2019).
Frontiers in Physiology, 10, 1065.
Universal atrial coordinates applied to visualisation, registration and construction of patient specific meshes.
Roney, C. H., Pashaei, A., Meo, M., Dubois, R., Boyle, P. M., Trayanova, N. A., \u2026 Vigmond, E. J. (2019).
Medical Image Analysis, 55, 65\u201375.
The left and right ventricles respond differently to variation of pacing delays in cardiac resynchronization therapy: A combined experimental- computational approach.
Willemen, E., Schreurs, R., Huntjens, P. R., Strik, M., Plank, G., Vigmond, E., \u2026 Lumens, J. (2019).
Frontiers in Physiology, 10, 17.
New insights on the cardiac safety factor: Unraveling the relationship between conduction velocity and robustness of propagation.
Boyle, P. M., Franceschi, W. H., Constantin, M., Hawks, C., Desplantez, T., Trayanova, N. A., & Vigmond, E. J. (2019).
Journal of Molecular and Cellular Cardiology, 128, 117\u2013128.
Propagation failure by TRPM4 Overexpression.
Gaur, N., Hof, T., Haissaguerre, M., & Vigmond, E. J. (2019).
Biophysical Journal, 116(3), 469\u2013476.
A technique for measuring anisotropy in atrial conduction to estimate conduction velocity and atrial fibre direction.
Roney, C. H., Whitaker, J., Sim, I., O\u2019Neill, L., Mukherjee, R. K., Razeghi, O., \u2026 Niederer, S. A. (2019).
Computers in Biology and Medicine, 104, 278\u2013290.

2018

Determinants of new wavefront locations in cholinergic atrial fibrillation.
Roney, C. H., Ng, F. S., Debney, M. T., Eichhorn, C., Nachiappan, A., Chowdhury, R. A., \u2026 Vigmond, E. J. (2018).
European Pacing, Arrhythmias, and Cardiac Electrophysiology, 20(suppl_3), iii3\u2013iii15.
Patient-specific simulations predict efficacy of ablation of interatrial connections for treatment of persistent atrial fibrillation.
Roney, C. H., Williams, S. E., Cochet, H., Mukherjee, R. K., O\u2019Neill, L., Sim, I., \u2026 Niederer, S. A. (2018).
European Pacing, Arrhythmias, and Cardiac Electrophysiology, 20(suppl_3), iii55\u2013iii68.
Compartmentalized structure of the moderator band provides a unique substrate for macroreentrant ventricular tachycardia.
Walton, R. D., Pashaei, A., Martinez, M. E., Constantin, M., Duchateau, J., Bear, L., \u2026 Bernus, O. (2018).
Circulation. Arrhythmia and Electrophysiology, 11(8), e005913.
Determinants of atrial bipolar voltage: Inter electrode distance and wavefront angle.
Beheshti, M., Magtibay, K., Mass\xe9, S., Porta-Sanchez, A., Haldar, S., Bhaskaran, A., \u2026 Nanthakumar, K. (2018).
Computers in Biology and Medicine, 102, 449\u2013457.
Wavelength and fibrosis affect phase singularity locations during atrial fibrillation.
Saha, M., Roney, C. H., Bayer, J. D., Meo, M., Cochet, H., Dubois, R., & Vigmond, E. J. (2018).
Frontiers in Physiology, 9, 1207.
Localized structural alterations underlying a subset of unexplained sudden cardiac death.
Ha\xefssaguerre, M., Hocini, M., Cheniti, G., Duchateau, J., Sacher, F., Puyo, S., \u2026 Dubois, R. (2018).
Circulation. Arrhythmia and Electrophysiology, 11(7), e006120.
Variability in pulmonary vein electrophysiology and fibrosis determines arrhythmia susceptibility and dynamics.
Roney, C. H., Bayer, J. D., Cochet, H., Meo, M., Dubois, R., Ja\xefs, P., & Vigmond, E. J. (2018).
PLoS Computational Biology, 14(5), e1006166.
Universal ventricular coordinates: A generic framework for describing position within the heart and transferring data.
Bayer, J., Prassl, A. J., Pashaei, A., Gomez, J. F., Frontera, A., Neic, A., \u2026 Vigmond, E. J. (2018).
Medical Image Analysis, 45, 83\u201393.

2017

Fractionated electrograms with ST-segment elevation recorded from the human right ventricular outflow tract.
Vigmond, E. J., Efimov, I. R., Rentschler, S. L., Coronel, R., & Boukens, B. J. (2017).
HeartRhythm Case Reports, 3(11), 546\u2013550.
Efficient computation of electrograms and ECGs in human whole heart simulations using a reaction-eikonal model.
Neic, A., Campos, F. O., Prassl, A. J., Niederer, S. A., Bishop, M. J., Vigmond, E. J., & Plank, G. (2017).
Journal of Computational Physics, 346, 191\u2013211.
Spatial resolution requirements for accurate identification of drivers of atrial fibrillation.
Roney, C. H., Cantwell, C. D., Bayer, J. D., Qureshi, N. A., Lim, P. B., Tweedy, J. H., \u2026 Ng, F. S. (2017).
Circulation. Arrhythmia and Electrophysiology, 10(5), e004899.
Rate-dependent role of IKur in human atrial repolarization and atrial fibrillation maintenance.
Aguilar, M., Feng, J., Vigmond, E., Comtois, P., & Nattel, S. (2017).
Biophysical Journal, 112(9), 1997\u20132010.

2016

Novel radiofrequency ablation strategies for terminating atrial fibrillation in the left atrium: A simulation study.
Bayer, J. D., Roney, C. H., Pashaei, A., Ja\xefs, P., & Vigmond, E. J. (2016).
Frontiers in Physiology, 7, 108.
Percolation as a mechanism to explain atrial fractionated electrograms and reentry in a fibrosis model based on imaging data.
Vigmond, E., Pashaei, A., Amraoui, S., Cochet, H., & Hassaguerre, M. (2016).
Heart Rhythm, 13(7), 1536\u20131543.
Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation.
Haissaguerre, M., Shah, A. J., Cochet, H., Hocini, M., Dubois, R., Efimov, I., \u2026 Trayanova, N. (2016).
The Journal of Physiology, 594(9), 2387\u20132398.
Modeling our understanding of the His-Purkinje system.
Vigmond, E. J., & Stuyvers, B. D. (2016).
Progress in Biophysics and Molecular Biology, 120(1\u20133), 179\u2013188.

2015

Decrement evoked potential mapping: Basis of a mechanistic strategy for ventricular tachycardia ablation.
Jackson, N., Gizurarson, S., Viswanathan, K., King, B., Mass\xe9, S., Kusha, M., \u2026 Nanthakumar, K. (2015).
Circulation. Arrhythmia and Electrophysiology, 8(6), 1433\u20131442.
Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load.
Campos, F. O., Shiferaw, Y., Prassl, A. J., Boyle, P. M., Vigmond, E. J., & Plank, G. (2015).
Cardiovascular Research, 107(1), 175\u2013183.

2014

A bilayer model of human atria: mathematical background, construction, and assessment.
Labarthe, S., Bayer, J., Coudi\xe8re, Y., Henry, J., Cochet, H., Ja\xefs, P., & Vigmond, E. (2014).
European Pacing, Arrhythmias, and Cardiac Electrophysiology, 16 Suppl 4, iv21\u2013iv29.
Influence of the Purkinje-muscle junction on transmural action potential duration profiles.
Walton, R. D., Martinez, M. E., Bishop, M. J., Hocini, M., Ha\xefssaguerre, M., Plank, G., \u2026 Vigmond, E. J. (2014).
Cardiovascular Research, 103(4), 629\u2013640.
Dantrolene improves survival after ventricular fibrillation by mitigating impaired calcium handling in animal models.
Zamiri, N., Mass\xe9, S., Ramadeen, A., Kusha, M., Hu, X., Azam, M. A., \u2026 Nanthakumar, K. (2014).
Circulation, 129(8), 875\u2013885.

2013 and Older

Transmural IK(ATP) heterogeneity as a determinant of activation rate gradient during early ventricular fibrillation: mechanistic insights from rabbit ventricular models.
Boyle, P. M., Mass\xe9, S., Nanthakumar, K., & Vigmond, E. J. (2013).
Heart Rhythm, 10(11), 1710\u20131717.
Accelerating cardiac bidomain simulations using graphics processing units.
Neic, A., Liebmann, M., Hoetzl, E., Mitchell, L., Vigmond, E. J., Haase, G., & Plank, G. (2012).
IEEE Transactions on Biomedical Engineering, 59(8), 2281\u20132290.
A Novel Rule-Based Algorithm for Assigning Myocardial Fiber Orientation to Computational Heart Models.
Bayer, J., Blake, R., Plank, G., & Trayanova, N. (05 2012).
Annals of Biomedical Engineering, 40, 2243\u20132254.
Solving the coupled system improves computational efficiency of the bidomain equations.
Southern, J. A., Plank, G., Vigmond, E. J., & Whiteley, J. P. (2009).
IEEE Transactions on Bio-Medical Engineering, 56(10), 2404\u20132412.
Computational techniques for solving the bidomain equations in three dimensions.
Vigmond, E. J., Aguel, F., & Trayanova, N. A. (2002).
IEEE Transactions on Bio-Medical Engineering, 49(11), 1260\u20131269.
Book Chapters

Vigmond, E. J. (2020). Tissue and organ scale modeling: coupled cells, wave propagation, simulated arrhythmia. In 2053-2563. Modeling and Simulating Cardiac Electrical Activity (pp. 7\u20131 to 7\u201323).

Vigmond, E., & Plank, G. (2018). Cardiac modeling. Encyclopedia of Biomedical Engineering, 1st edition, Elsevier.

Bishop MJ, Arevalo HJ, Boyle PM, Trayanova NA, Vigmond E, Plank G. Chapter 14. Computational Cardiac Electrophysiology: Modeling Tissue and Organ. In: Pahlm O, Wagner GS. eds. Multimodal Cardiovascular Imaging: Principles and Clinical Applications. The McGraw-Hill Companies; 2011.

Conference Proceedings

2024 (Conference)

Cabanis, P., Magat, J., Vaillant, F., Abell, E., Michel, C., Pasdois, P., \u2026 Others. (2024). Characterization of the Septal Discontinuity in Ex-vivohuman Hearts Using DTI. Journal of Cardiovascular Magnetic Resonance, 26.

Zolotarev, A., Rodero, C., Narayan, S. M., Vigmond, E. J., Plank, G., Niederer, S. A., & Roney, C. H. (2024). ANATOMICAL AND PHYSIOLOGICAL FEATURES IMPROVE AF ABLATION OUTCOME PREDICTION. Heart Rhythm, 21(5), S561\u2013S562.

2023 (Conference)

Biasi, N., Seghetti, P., Tognetti, A., & Vigmond, E. J. (2023). Incremental Pacing Induces Sustained Reentry in a Computational Model of Brugada Syndrome. 2023 Computing in Cardiology (CinC), 50, 1\u20134. IEEE.

Sobota, V., Augustin, C. M., Nordmeyer, S., Vigmond, E. J., & Bayer, J. D. (2023). Overall fibrosis content rather than regional differences in extracellular volume alters ventricular conduction in aortic stenosis patients. Europace, 25(Supplement_1).

2022 (Conference)

Sobota, V., Nordmeyer, S., Augustin, C., Plank, G., Vigmond, E. J., & Bayer, J. D. (2022). A Method for Incorporating Changes in Extracellular Volume and Myocyte Size Into the Cardiac Bidomain Equations. 2022 Computing in Cardiology (CinC), 498, 1\u20134. IEEE.

2021 (Conference)

Barber, F., Langfield, P., Lozano, M., Garcia-Fernandez, I., Duchateau, J., Hocini, M., \u2026 Sebastian, R. (2021). Personalization of ventricular cardiac conduction system models to reproduce patient electrocardiogram. 2021 Computing in Cardiology (CinC), 48, 1\u20134. IEEE.

2020 (Conference)

S\xe1nchez, J., Nothstein, M., Neic, A., Huang, Y.-L., Prassl, A. J., Klar, J., \u2026 Others. (2020). openCARP: an open sustainable framework for in-silico cardiac electrophysiology research. 2020 Computing in Cardiology, 1\u20134. IEEE.

2019 (Conference)

Meo, M., Duch\xe2teau, J., Bayer, J., Pambrun, T., Roney, C. H., Vigmond, E. J., \u2026 Others. (2019). An Automated Platform to Standardize Position in the Left Atrium and Map Electrophysiological Data. 2019 Computing in Cardiology (CinC). IEEE.

2018 (Conference)

Gillette, K., Prassl, A., Neic, A., Plank, G., Bayer, J., & Vigmond, E. (2018). Automatic Generation of Bi-Ventricular Models of Cardiac Electrophysiology for Patient Specific Personalization Using Non-Invasive Recordings. 2018 Computing in Cardiology Conference (CinC), 45, 1\u20134.

2017 (Conference)

Gillette, K., Prassi, A., Bayer, J., Vigmond, E. J., Neic, A., & Plank, G. (2017). Patient-specific parameterization of a left-ventricular model of cardiac electrophysiology using electrocardiographic recordings. 2017 Computing in Cardiology (CinC), 1\u20134. IEEE.

2014 & Older (Conference)

Walton, R., Bernus, O., & Vigmond, E. J. (2014). Effect of Purkinje-Myocyte Junctions on Transmural Action Potential Duration Profiles. XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013, 1868\u20131870.

Vigmond, E. J., Suzuki, G., Faris, P., Kimber, S., & Leon, J. (2010). DEFIBRILLATION SUCCESS IS UNCORRELATED WITH SIGNAL ORGANIZATION OF ICD ELECTROGRAMS AND SHOCK TIMING. CANADIAN JOURNAL OF CARDIOLOGY, 26, 59D-59D.

Vigmond, E. J., Aguel, F., & Trayanova, N. A. (2002). Parallel multigrid preconditioner for the cardiac bidomain model. Proceedings of the IEEE EMBS.